Opioid Toxicity clinical trials at UC Cancer
1 research study open to eligible people
Showing trials for
Pupillary Unrest as an Indicator of Central Opioid Effect in Subjects 40-60 Years of Age
open to eligible people ages 40-60
This study will establish the relationship between magnitude of opioid exposure and a pupillary measure referred to as PUAL (pupillary unrest in ambient light), in subjects aged 40-60. Previous investigation demonstrated that loss of PUAL was a sensitive, discriminative indicator of opioid toxicity and respiratory depression among subjects aged 20-40 years old. Population data indicate that pupil size and PUAL decline slightly with age. The investigators will explore whether PUAL proves to be a sensitive indicator of opioid exposure and respiratory depression in this older group.