A Study of Selpercatinib (LOXO-292) in Participants With Advanced Solid Tumors, RET Fusion-Positive Solid Tumors, and Medullary Thyroid Cancer (LIBRETTO-001)
Non-Small Cell Lung Cancer Medullary Thyroid Cancer Colon Cancer Any Solid Tumor LOXO-292 KIF5B-RET M918T CCDC6-RET RET-PTC1 NCOA4-RET RET-PTC RET-PTC3 RET-PTC4 PRKAR1A-RET RET-PTC2 GOLGA5-RET RET-PTC5 ERC1-RET KTN1-RET RET-PTC8 HOOK3-RET PCM1-RET TRIM24-RET RET-PTC6 TRIM27-RET TRIM33-RET RET-PTC7 AKAP13-RET FKBP15-RET SPECC1L-RET TBL1XR1-RET BCR-RET FGRF1OP-RET RFG8-RET RET-PTC9 ACBD5-RET MYH13-RET CUX1-RET KIAA1468-RET FRMD4A-RET SQSTM1-RET AFAP1L2-RET PPFIBP2-RET EML4-RET PARD3-RET G533C C609F C609G C609R C609S C609Y C611F C611G C611S C611Y C611W C618F C618R C618S C620F C620R C620S C630R C630Y D631Y C634F C634G C634R C634S C634W C634Y K666E E768D L790F V804L V804M A883F S891A R912P CLIP1-RET Y806C RET fusion RET alteration RET mutation RET rearrangement RET translocation Neoplasms by Site Neoplasms Lung Neoplasms Carcinoma, Non-Small-Cell Lung Cancer of Lung Cancer of the Lung Lung Cancer Neoplasms, Lung Neoplasms, Pulmonary Pulmonary Cancer Pulmonary Neoplasms Respiratory Tract Neoplasms Lung Diseases Respiratory Tract Diseases Carcinoma, Bronchogenic Bronchial Neoplasms Papillary Thyroid Cancer Thyroid Diseases Thyroid Neoplasms Cancer of the Thyroid Cancer of Thyroid Neoplasms, Thyroid Thyroid Ademona Thyroid Cancer Thyroid Carcinoma Endocrine System Diseases Endocrine Gland Neoplasms Head and Neck Neoplasms Thoracic Neoplasms CNS tumor Primary CNS tumor Cancer of Colon Cancer of the Colon Colon Neoplasms Colonic Cancer Neoplasms, Colonic Malignant tumor of Breast Mammary Cancer Mammary Carcinoma, Human Mammary Neoplasm, Human Neoplasms, Breast Tumors, Breast Human Mammary Carcinoma Malignant Neoplasm of Breast Breast Carcinoma Breast Tumors Cancer of the Breast Breast Neoplasms Breast Cancer RET Inhibitor MTC NSCLC selpercatinib neo-adjuvant treatment in early stage NSCLC Colonic Neoplasms Carcinoma, Neuroendocrine
Lead Scientists at UC Cancer
- Lyudmila Bazhenova (ucsd)
Dr. Bazhenova’s clinical practice and research concentrate on lung cancer, particularly as this relates to females and non-smokers. She actively participates in cooperative group trials, and takes an active role in designing and implementing clinical investigations, including phase II studies and correlative science projects with several UCSD investigators.
- Jonathan W Goldman (ucla)
HS Associate Clinical Professor, Medicine. Authored (or co-authored) 86 research publications
- Hyunseok Kang (ucsf)
Dr.Hyunseok "Hyu" Kang is a medical oncologist and a clinician scientist focusing on head and neck cancers including squamous cell carcinomas of head and neck (SCCHN), salivary gland cancers, thyroid cancers and other rare cancers of head and neck.
- accepting new patients
- Start Date
- Completion Date
- Loxo Oncology, Inc.
- Phase 1/2 research study
- Study Type
- Expecting 875 study participants
- Last Updated