Summary

Eligibility
for females ages 18 years and up (full criteria)
Location
at UCLA
Dates
study started
estimated completion
Principal Investigator
John Glaspy, MD (ucla)

Description

Summary

This is a Phase 1/1b, open-label, dose-escalation, and dose-expansion study to evaluate the safety, tolerability, pharmacokinetic (PK), pharmacodynamic (PD), and clinical activity of AB928 in combination with pegylated liposomal doxorubicin (PLD) with or without IPI-549 in participants with advanced metastatic triple-negative breast cancer (TNBC) or ovarian cancer, and AB928 in combination with nanoparticle albumin-bound-paclitaxel (NP) in participants with advanced metastatic TNBC.

Official Title

A Phase 1/1b Study to Evaluate the Safety and Tolerability of Immunotherapy Combinations in Participants With Breast or Gynecologic Malignancies

Details

In the dose escalation phase, the following will be assessed:

  • Arm A: escalating doses of AB928 in combination with PLD at standard doses will be assessed in participants with advanced metastatic triple-negative breast cancer or ovarian cancer. Eligible participants will receive oral administration of AB928 as well as intravenous (IV) infusion of PLD. The recommended dose (RDE) for expansion Arms 1 and 2 and escalation Arm C will be determined upon completion of this dose escalation arm.
  • Arm B: escalating doses of AB928 in combination with the NP at standard doses will also be assessed in participants with advanced metastatic TNBC. Eligible participants will receive oral administration of AB928 as well as NP infusion. The RDE of AB928 will be determined upon completion of this dose escalation arm.
  • Arm C: escalating doses of IPI-549 in combination with the RDE of AB928 (from Arm A) and PLD at standard doses will be assessed in participants with advanced metastatic TNBC or ovarian cancer. Eligible participants will receive oral administration of both AB928 and IPI-549 as well as IV infusion of PLD. The RDE of IPI-549 for expansion Arm 4 will be determined upon completion of this dose escalation arm.

In the dose expansion phase, the following will be assessed:

  • Arms 1 and 2: AB928 at the RDE in combination with PLD at standard doses may be assessed in participants with advanced metastatic TNBC or ovarian cancer.
  • Arm 3: AB928 at the RDE in combination with NP at standard doses may be assessed in participants with advanced metastatic TNBC.
  • Arm 4: AB928 and IPI-549 at the RDE in combination with PLD at standard doses may be assessed in participants with advanced metastatic TNBC.

Overall duration of treatment will depend on how well the treatment is tolerated. Treatment may continue until unacceptable toxicity or progressive disease or other reasons specified in the protocol.

Keywords

TNBC - Triple-Negative Breast Cancer Ovarian Cancer Triple Negative Breast Cancer TNBC Breast Neoplasms Ovarian Neoplasms Triple Negative Breast Neoplasms Paclitaxel Doxorubicin Liposomal doxorubicin Albumin-Bound Paclitaxel IPI-549 Pegylated liposomal doxorubicin (PLD) nanoparticle albumin-bound paclitaxel (NP)

Eligibility

For females ages 18 years and up

  1. Female participants, 18 years or older
  2. Measurable disease per radiographic evaluation
  3. Performance status 0 or 1
  4. Available archival tissue sample (within 2 years) or a fresh tumor biopsy may be required
  5. Adequate organ, cardiac, and bone marrow function
  6. Dose escalation
  7. Participants with breast cancer:
  8. Locally advanced or metastatic triple negative breast cancer (ER-negative, PgR-negative, and HER2-negative according to ASCO/CAP guidelines) with disease progression
  9. No available alternative or curative therapy
  10. Participants may have received any number of prior therapies for advanced/recurrent and progressive disease
  11. Participants with ovarian cancer:
  12. Locally advanced or metastatic ovarian cancer with disease progression
  13. No available alternative or curative therapy Participants may have received any number of prior therapies for advanced/recurrent and progressive disease
  14. Dose expansion
  15. Participants with breast cancer:
  16. Locally advanced or metastatic triple negative breast cancer (ER-negative, PgR-negative, and HER2-negative according to ASCO/CAP guidelines)
  17. Disease progression after no more than 3 prior lines of therapy
  18. Participants with ovarian cancer:
  19. Locally advanced or metastatic ovarian cancer that is platinum-resistant
  20. Disease progression after no more than 3 prior lines of therapy

Exclusion:

  1. Received a live, attenuated vaccine within 4 weeks prior to first study treatment
  2. Prior anticancer treatment including approved agents, systemic radiotherapy, or investigational therapy within 4 weeks prior first study treatment
  3. Cancer other than the disease under study within 2 years prior to study entry, except for some cancers with a low risk of spreading like non-melanoma skin cancers
  4. Inability to swallow oral medications
  5. Participant is breastfeeding, pregnant, or expects to become pregnant during the study
  6. Active autoimmune disease or documented history of autoimmune disease within 2 years prior to first study treatment
  7. History of peptic ulcer or stomach bleeding within 6 months prior to first study treatment
  8. Use of drugs contraindicated by the protocol within 4 weeks prior to and during study treatment
  9. Prior treatment with drugs that suppress the immune system within 2 weeks prior to first study treatment
  10. . Presence of metastases in the brain or cancer spreading into the cerebrospinal fluid -CSF (leptomeningeal disease)
  11. . HIV, Hepatitis B, and C test results negative prior to first study treatment
  12. . Major surgery within 4 weeks prior to first study treatment
  13. . Participants who have previously received maximum cumulative lifetime anthracycline dosage or baseline ejection fraction <50% (on heart echography)

Locations

  • University of California, Los Angeles accepting new patients
    Los Angeles California 90095 United States
  • Comprehensive Cancer Centers of Nevada accepting new patients
    Las Vegas Nevada 89169 United States

Lead Scientist at UC Cancer

  • John Glaspy, MD (ucla)
    Professor, Medicine. Authored (or co-authored) 120 research publications.

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
Arcus Biosciences, Inc.
ID
NCT03719326
Phase
Phase 1
Study Type
Interventional
Last Updated