Summary

Eligibility
for people ages 18 years and up (full criteria)
Location
at UCLA
Dates
study started
estimated completion

Description

Summary

The purpose of this study is to determine the safety and efficacy of MILs™ - NSCLC alone and in combination with nivolumab in subjects with locally advanced and unresectable or metastatic NSCLC who are refractory or relapsing to a PD-1 containing regimen.

Official Title

A Phase 2a, Open-Label, Multi-Center Study to Assess the Efficacy and Safety of Marrow Infiltrating Lymphocytes - Non-Small Cell Lung Cancer (MILs™ - NSCLC) Alone or in Combination With Nivolumab in Subjects With Locally Advanced and Unresectable or Metastatic NSCLC Previously Treated With Anti-PD-1

Details

This study will examine the safety and efficacy of Marrow Infiltrating Lymphocytes-Non-Small Cell Lung Cancer (MILs™ - NSCLC) combined with nivolumab in subjects with locally advanced and unresectable and metastatic NSCLC who were refractory to, or have relapsed on, an anti-PD-1 containing regimen. MILs™ - NSCLC are an adoptive cell therapy product derived via the activation and expansion of bone marrow T cells. Subjects will have bone marrow harvested during the Screening Period which will be used to manufacture the MILs™ - NSCLC. The MILs™ - NSCLC will then be administered on Day 0. Nivolumab will be administered on Day 1 and will continue every four weeks until treatment discontinuation.

Keywords

Non Small Cell Lung Cancer Lung Cancer Lung Cancer Metastatic Lung Cancer, Non-small Cell Non Small Cell Lung Cancer Metastatic NSCLC Non-small Cell Lung Cancer Non-small Cell Lung Cancer Metastatic metastatic locally advanced unresectable cell therapy autologous cell therapy adoptive cell therapy Lung Neoplasms Carcinoma, Non-Small-Cell Lung Neoplasms Nivolumab MILs™ - NSCLC MILs™ - NSCLC plus nivolumab

Eligibility

You can join if…

Open to people ages 18 years and up

  1. Eastern Cooperative Oncology Group (ECOG) Performance Status 0 or 1.
  2. Locally advanced and unresectable, or metastatic NSCLC.
  3. Histologically or cytologically confirmed, either squamous or non-squamous NSCLC.
  4. Measurable disease as per RECIST 1.1 with radiographic evidence of disease progression.
  5. Willingness to undergo bone marrow aspiration (BMA).
  6. No more than one treatment regimen following an anti-PD-1 antibody containing treatment regimen prior to BMA collection
  7. ≥ 21 days have lapsed since last cytotoxic chemotherapy treatment prior to collection of the BMA.
  8. Previous treatment with the appropriate targeted therapy if the subject has known EGFR/ALK/ROS1 rearrangements.
  9. Willingness to provide a fresh tumor biopsy during Screening Period or formalin-fixed, paraffin-embedded tissue collected at the time of most recent relapse. Note: Archival tissue regardless of biopsy date may be considered.
  10. . Adequate renal, hepatic and bone marrow function defined as total bilirubin </= 1.5 x ULN (except for subjects with Gilbert's disease ≤ 3.0 x ULN with direct bilirubin </= 1.5 x ULN ). Aminotransferase (AST) / Alanine Aminotransferase (ALT) </= 2.5 X ULN (subjects with liver involvement will be allowed </= 5.0 X ULN). Serum creatinine </= 1.5 x ULN; if serum creatinine is 1.5 to 2.0 × ULN, then the creatinine clearance (calculated using the Cockcroft-Gault formula or measured) must be ≥ 40 mL/min. Lymphocyte >/= 1.0 x 109/L. ANC >/= 1.5 x 109/L. Platelets >/= 100 × 109/L. WBC >/= 2.0 ×109/L. Hemoglobin > 9.0 g/dL.

  11. . Women of childbearing potential and male subjects (even if they are surgically sterilized or had a vasectomy) and their partners must agree to abstain or to use an effective form of birth control during the study for at least 6 months following administration of the last dose of lymphodepletion or for at least 5 months following the last dose of nivolumab for females and 7 months for males, whichever is longer. In addition, male subjects must not donate sperm during this period.
  12. . Capable of giving and has provided a signed ICF, which includes compliance with the requirements and restrictions listed in the ICF and in this protocol.

You CAN'T join if...

  1. Insufficient activation/expansion of T cells or other problems with the subject's MILs™ - NSCLC product which would prohibit administration.
  2. Major surgical procedure within 7 days of the first dose of lymphodepletion treatment.
  3. Prior malignancy active within the previous 3 years from date of BMA collection except for locally curable cancers that have been apparently cured, such as basal or squamous cell skin cancer, superficial bladder cancer, or carcinoma in situ of the prostate, cervix, or breast.
  4. Subjects with symptomatic uncontrolled brain metastases requiring treatment with steroids or anti-seizure medications within 28 days prior to the BMA are excluded. However, participants with brain metastases that have been previously treated and are stable on subsequent scan(s) are allowed and subjects with untreated possible brain metastases that are new at the time of screening and are < 1 cm and asymptomatic are allowed.
  5. Infection requiring treatment with intravenous antibiotics, antifungal, or antiviral agents within 7 days prior to the BMA.
  6. Presence of an autoimmune disease requiring active systemic treatment.
  7. Clinically significant, uncontrolled cardiovascular disease, including congestive heart failure Grade III or IV according to the New York Heart Association classification, myocardial infarction or unstable angina within the previous 6 months prior to BMA collection.
  8. Known diagnosis of human immunodeficiency virus (HIV) or active viral hepatitis.
  9. Administration of neutrophil growth factor support within 14 days prior to the BMA.
  10. . Use of systemic corticosteroids (glucocorticoids) for greater than one day within 28 days prior to the BMA.
  11. . Planned use of systemic corticosteroids (glucocorticoids) for greater than one day within 28 days prior to MILs™ - NSCLC administration.
  12. . Prior radiation to both sides of the pelvis. Prior radiation to one side of the pelvis is permitted as long as the other side of the pelvis.
  13. . Subjects with history of life-threatening toxicity related to prior immune therapy except those that are unlikely to re-occur with standard countermeasures.
  14. . Receipt of live attenuated vaccine within 30 days of planned Day 0.
  15. . History of allergy or hypersensitivity to MILs™-NSCLC, cyclophosphamide, fludarabine, nivolumab or their components.
  16. . Pregnant or lactating females.
  17. . Prior or ongoing clinically significant illness, medical condition, surgical history, physical finding, or laboratory abnormality that, in the Investigator's opinion, could affect the safety of the subject or impair the assessment of study results.
  18. . Unwilling or unable to comply with the protocol.

Locations

  • University of California - Los Angeles accepting new patients
    Los Angeles California 90095 United States
  • City of Hope accepting new patients
    Duarte California 91010 United States

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
WindMIL Therapeutics
ID
NCT04069936
Phase
Phase 2
Study Type
Interventional
Last Updated