for people ages 46 years and up (full criteria)
study started
estimated completion
Principal Investigator
by Denise Aberle, MD (ucla)
Headshot of Denise Aberle
Denise Aberle



DECAMP 1 PLUS aims to improve the efficiency of the diagnostic evaluation of patients with indeterminate pulmonary nodules (8-25 mm). Molecular biomarkers for lung cancer diagnosis measured in minimally invasive and non-invasive biospecimens may be able to distinguish between malignant or benign indeterminate pulmonary nodules in high-risk smokers. Ultimately, this study aims to validate molecular as well as clinical and imaging biomarkers of lung cancer in individuals with indeterminate lung nodules.


The Detection of Early lung Cancer Among Military Personnel (DECAMP) consortium is a multidisciplinary and translational research program that previously initiated the DECAMP-1 and DECAMP-2 studies for lung cancer early detection. Now, with the support of Johnson and Johnson, 3 Veterans Administration Hospitals (VAH), 3 Military Treatment Facilities (MTF) and 12 academic hospitals as clinical study sites, several molecular biomarker laboratories, along with Biostatics, Bioinformatics, Pathology and Biorepository cores, we are expanding our work in lung cancer early detection.


Pulmonary Disease, Indeterminate pulmonary nodules, Molecular biomarkers for lung cancer diagnosis, Imaging for lung cancer diagnosis, High risk smokers, Lung Neoplasms, Biosamples of airway and blood, Incidental


You can join if…

Open to people ages 46 years and up

  • Radiologic diagnosis of solid indeterminate pulmonary nodule (0.8 to 2.5 cm) identified in the past 3 months OR semi-solid (mixed density) nodule with solid component of at least 0.6 cm identified in the past 12 months; must be of appropriate size at enrollment.
  • CT scan completed within 3 months prior to enrollment
  • Able to tolerate all biospecimen collection as required by protocol
  • Able to comply with standard of care follow up visits including clinical exams, diagnostic work-ups, and imaging for approximately three years from enrollment
  • Able to complete the Patient Lung History questionnaire with study staff

    Arm 1 - Screening

  • Age 55-77 years old
  • Current and former smokers with 30 pack-years or more(and quit less than 15 years ago)

    Arm 2 - Incidental

  • Age > 45 years old
  • Current and former smokers with 10 pack-years or more(and quit less than 15 years ago)

You CAN'T join if...

  • History or previous diagnosis of primary lung cancer, metastatic lung cancer, or any other non-lung cancer within 5 years (not including non-melanoma skin cancer)
  • Symptoms of lung cancer (unexplained weight loss 10 lbs or more in 3 months, recent hemoptysis)
  • Diagnosis of pure ground glass opacities for the target lesion on chest CT within the last 12 months (i.e., mixed features on the target lesion and pure ground glass opacity on non-target lesions are acceptable as mentioned above)


  • University of California Los Angeles accepting new patients
    Los Angeles California 90095 United States
  • VA Greater LA Healthcare System accepting new patients
    Los Angeles California 90095 United States
  • Naval Medical Center San Diego accepting new patients
    San Diego California 92134 United States

Lead Scientist at UC Cancer

  • Denise Aberle, MD (ucla)
    Professor, Radiological Sciences, Medicine. Authored (or co-authored) 103 research publications


accepting new patients
Start Date
Completion Date
Boston University
Study Type
Expecting 1000 study participants
Last Updated