The most common tissue expander-related infections are from Staphylococcus and Pseudomonas species. In addition, from breast tissue microbiome studies, Staphylococcus and Pseudomonas show variable abundance across samples. The investigator hypothesizes that patients undergoing mastectomy with high initial abundance of Staphylococcus and/or Pseudomonas are more likely to develop subsequent tissue expander-related infections from these respective organisms.
Microbiome and Association With Implant Infections: Investigating the Impact of Antibiotics on the Gut and Breast Microbiomes Post-mastectomy With Implant-based Breast Reconstruction
PRIMARY OBJECTIVE: a) To determine the feasibility of breast microbiome sampling using the study techniques SECONDARY OBJECTIVES: 1. To define the differences in the gut and breast microbiomes between patients undergoing mastectomy with implant-based reconstruction who develop post-operative implant infection and those who do not. 2. To determine the effects of post-operative antibiotics on the gut and breast microbiomes after mastectomy with implant-based reconstruction. Patients are followed-up for 90 days after undergoing implant-based reconstruction.